However, even substances that are found naturally in the body can have unpredictable results when taken in higher than normal quantities and in different formulations. This is particularly true with patients who are taking multiple medications or who have other diagnosed illness. For example:. Request an Appointment. Search form Search. Twitter Facebook YouTube.
You are here Home Share. What is Glucosamine and Chondroitin Sulfate? Typical dosage is mg for glucosamine sulfate and mg for chondroitin sulfate, taken once daily. For body weight less than lbs, the dose is generally reduced to mg for glucosamine sulfate and mg for chondroitin sulfate. Duration of treatment has not yet been determined. Reported improvement e. The study was stopped early for an unusual reason — those taking the supplement actually reported worse symptoms than those taking a placebo.
This raises the possibility that taking glucosamine and chondroitin might make your joints feel worse than doing nothing. Does this spell the end of people taking glucosamine, chondroitin, or both? While the evidence of benefit is certainly not compelling, some studies have found that these supplements provide modest benefit and people who feel it is helping them may not care so much about individual studies. Even if a treatment is not effective on average, there may be folks who, for whatever reason, get real relief from it.
And, even if the benefit is from the placebo effect, the benefit is real and that is hard to give up on. More information. For the Knee or Hip Glucosamine Major studies of glucosamine for osteoarthritis of the knee have had conflicting results.
Most participants in the study had mild knee pain. Those who received the prescription drug had better short-term pain relief at 6 months than those who received a placebo. Overall, those who received the supplements had no significant improvement in knee pain or function, although the investigators saw evidence of improvement in a small subgroup of patients with moderate-to-severe pain who took glucosamine and chondroitin together.
In several European studies, participants reported that their knees felt and functioned better after taking glucosamine. The study participants took a large, once-a-day dose of a preparation of glucosamine sulfate sold as a prescription drug in Europe. It may be because of differences in the types of glucosamine used glucosamine hydrochloride in the NIH study vs.
More than 20 studies have looked at the effect of chondroitin on pain from knee or hip osteoarthritis. The quality of the studies varied and so did the results. Joint Structure. For Other Parts of the Body Only a small amount of research has been done on glucosamine and chondroitin for osteoarthritis of joints other than the knee and hip. Chondroitin for osteoarthritis of the hand A 6-month trial of chondroitin in patients with severe osteoarthritis of the hand showed that it may improve pain and function.
Glucosamine for osteoarthritis of the jaw One study of 45 patients with osteoarthritis of the jaw showed that those given glucosamine had less pain than those given ibuprofen. Glucosamine for chronic low-back pain and osteoarthritis of the spine A Norwegian trial involving people with chronic low-back pain and osteoarthritis of the lower spine found that participants who received glucosamine fared the same at 6 months as those who received placebo.
No serious side effects have been reported in large, well-conducted studies of people taking glucosamine, chondroitin, or both for up to 3 years.
However, glucosamine or chondroitin may interact with the anticoagulant blood-thinning drug warfarin Coumadin. A study in rats showed that long-term use of moderately large doses of glucosamine might damage the kidneys. Glucosamine might affect the way your body handles sugar, especially if you have diabetes or other blood sugar problems , such as insulin resistance or impaired glucose tolerance.
More to Consider. If your joints hurt, see your health care provider. Some diseases that cause joint pain—such as rheumatoid arthritis—may need immediate treatment. If you take warfarin or have blood sugar problems, make sure you talk to your doctor about potential side effects if you are considering or taking glucosamine or chondroitin supplements.
Help your health care providers give you better coordinated and safe care by telling them about all the health approaches you use. Give them a full picture of what you do to manage your health. Key References. Nicole Spiridakis. Nicole Spiridakis is a writer and editor with over 15 years of editorial experience. She writes mainly about food, cooking, and living a healthy, active lifestyle.
Her cookbook, "Flourless. Glucosamine supplements are made from the shells of shellfish such as lobsters and shrimp, or synthetically. Video of the Day. Tip There are no natural sources of glucosamine in food.
Natural Sources of Glucosamine. Dosage The Arthritis Foundation lists a recommended dosage of milligrams to 3 grams of glucosamine and chondroitin a day in divided doses for at least a month. Glucosamine Uses.
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